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KMID : 0380020100250040379
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Korean Journal of Biotechnology and Bioengineering
2010 Volume.25 No. 4 p.379 ~ p.386
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Preparation of PEG Microparticles Containing Coriander Essential Oil Using Supercritical PGSS Process
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Choi Jin-Ah
Lim Kyo-Bin
Ryu Jong-Hoon
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Abstract
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In the present study, biocompatible poly (ethylene glycol) (PEG) microparticles containing coriander essential oil were prepared using a supercritical particles from gas saturated solution (PGSS) process to improve the stability of the coriander oil. The effects of various process parameters such as temperature, pressure, and nozzle diameter on the morphology and entrapment efficiency of coriander oil loaded PEG microparticles were then investigated. A positive influence on the formation of spherical microparticles was observed with increasing temperature and decreasing pressure. Furthermore, somewhat more porous microparticles were produced with an increase in pressure. At a given temperature, the highest entrapment efficiency of coriander essential oil in PEG microparticles was observed under the lowest experimental pressure condition.
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KEYWORD
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PGSS, coriander essential oil, supercritical fluid, microparticle
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